In our globally connected world, the specter of foodborne and waterborne infections continues to cast a shadow over public health. These infections, ranging from commonplace gastrointestinal discomfort to severe, long-lasting conditions like mad cow disease and other neurodegenerative disorders, pose a persistent threat. One prominent example is the Hepatitis A Virus (HAV), which can be…
In cancer immunotherapy, the spotlight has fallen on STING as a pivotal target of recent interest. Biopharmaceutical companies worldwide are vigorously developing innovative therapies targeting STING with the goal of activating immune pathways to combat cancer cells. While these STING agonists have demonstrated promise in preclinical studies, a perplexing phenomenon has emerged in certain clinical trials. Contrary…
The COVID-19 pandemic, which emerged at the end of 2019, may have receded from public consciousness, but its impact continues to reverberate. Over the past three years, countries worldwide have grappled with multiple waves of widespread infection. Although many nations have now established immunity barriers, the risk of long COVID symptoms and recurrent infections still…
Cancer vaccines have shown clinical promise in driving tumor-reactive cell activation, proliferation, and effector functions. Cancer vaccine therapy, on the other hand, has not been successful in eradicating tumors and has limited efficacy in some patients. Cancer vaccination has been shown to be ineffective on its own in advanced and metastatic tumors, but it can…
In mammals, spermatogenesis (the differentiation of male germ cells after meiosis) is a highly coordinated developmental process controlled by a set of genes collectively known as spermatogenesis genes. Given that nuclear condensation during spermatogenesis gradually stops transcription, spermatogenic genes are transcribed early during the early stages of male reproductive development and stored as translationally inert…
In the realm of cancer therapy, immunotherapy has emerged as a beacon of hope, surpassing traditional methods. Monoclonal antibodies, renowned for their precision in targeting specific molecules, have played a crucial role in cancer treatment. However, their effectiveness is often limited by the complexities of tumor development when focusing on a single point. Enter bispecific…
In our globally connected world, the specter of foodborne and waterborne infections continues to cast a shadow over public health. These infections, ranging from commonplace gastrointestinal discomfort to severe, long-lasting conditions like mad cow disease and other neurodegenerative disorders, pose a persistent threat. One prominent example is the Hepatitis A Virus (HAV), which can be…
