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Atory) phase and immune reaction (acquired immunity). Female B/WF1 mice, a model for SLE and sSjS, develop several autoantibodies (e.g., anti-dsDNA and antinuclear antibodies: ANA) from younger ages (approximately 12 weeks of age) and thereafter immune-complexes- (ICs-) mediated glomerulonephritis (GN) develops with age, leading to overt disease (renal failure). On the other hand, production of an

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