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Tion, and additional tumor initiating pathways promote mammary carcinogenesis. We have previously shown that activated ERK1/2 levels and the migratory action of TERT-siSFRP1 cells are drastically reduced in response to TGF-R inhibition which is consistent with work described by Imamichi et al. showing that TGF- signaling mediates the cellular migration of breast cancer cells by ERK1/2 activation [
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Imulates and TGFBR inhibition represses EGR2 mRNA expression in both HMECs as well as MMECs (Additional file 2: Figure S2, Fig. 2). We have also observed that tumors derived from Sfrp1-/- mice express significantly higher levels of both Tgfb1 and Egr2 mRNA (data not shown). Dillon et al. revealed that Egr2 expression is upregulated in Erbb2 driven mammary tumors [25]. However, these researchers di
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